Curative Effect of Extracts of Sapindus Mukorossi and Rheum Emodi in CCl4 Induced Liver Cirrhosis in Male Rats
نویسندگان
چکیده
Aim : To study the curative effect of Sapindus mukorossi and Rheum emodi extracts in CCl4 induced liver cirrhosis in male rats. Methods : The dried powder of S. mukorossi & R. emodi was extracted successively with petroleum ether, benzene, chloroform and ethanol and concentrated in vacuum. The curative effect of the extracts of the fruit pericarp of S. mukorossi and rhizomes of R. emodi was studied using CCl4 induced liver cirrhosis in male rats. Biochemical parameters including serum transaminases [aspartate aminotransferase (AST) and alanine aminotransferase (ALT)] and alkaline phosphatase (ALP) in serum were analyzed. The biochemical findings were supplemented with histopathological examination of rat liver sections. Results : Extracts of the fruit pericarp of S. mukorossi (2.5mg/mL) and rhizomes of R. emodi (3.0 mg/mL) protected the rats from CCl4 induced liver cirrhosis as judged from histopathological evidences and serum marker enzyme activities.
منابع مشابه
Effect of Sapindus Mukorossi Saponin Fraction and Anthraquinone Fraction of Rheum Emodi on Ccl4 Induced Cytochrome P450 Damage in Wistar Rats
The cytochrome P450 protective activity of Sapindus mukorossi and Rheum emodi were evaluated against CCl4 induced prolongation of pentobarbitone sleep time in Wister rats. The fractions, at a dose of 0.2 g/kg,0.4g/kg p.o., Sapindus mukorossi, Rheum emodi significantly prevents the CCl4 induced prolongation of pentobarbitone sleep time (P<0.01), indicating the cytochrome P450 protection activity...
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